The effect of a rotating magnetic field on the antioxidant system in healthy volunteers - preliminary study

Authors: Cecerska-Heryc E, Glizniewicz M, Grygorcewicz B, Serwin N, Stodolak P, Slodzinska W, Birger R, Goszka M, Polikowska A, Budkowska M, Rakoczy R, Dolegowska B

Year: 2024 Apr 15

Category: Biophysics, Oxidative Stress Research

Journal: Scientific Reports

DOI: 10.1038/s41598-024-59391-y

URL: https://www.nature.com/articles/s41598-024-59391-y

Abstract

Overview

Oxidative stress arises from an imbalance between the generation of reactive oxygen species (ROS) and their removal by the body's antioxidant systems such as Superoxide Dismutase (SOD), Catalase (CAT), and Glutathione Peroxidase (GPx). Markers like total antioxidant capacity (TAC), reactive oxygen species modulator 1 (ROMO1), and malondialdehyde (MDA) signal damage from oxidative stress.

Study Purpose and Methods

  • Explores how a rotating magnetic field (RMF) impacts oxidative stress biomarkers.
  • 30 healthy volunteers (15 women and 15 men, mean age 24.8 ± 5.1) were divided into groups exposed to various RMF conditions: 1h/25Hz, 3h/25Hz, 1h/50Hz, and 3h/50Hz; an internal control group (CG) was used.
  • The RMF used magnetic inductions of 37.06 mT and 42.64 mT.
  • Serum samples were analyzed by ELISA for SOD, MDA, TAC, and ROMO1 activity/concentration.

Findings

  • RMF exposure significantly influences the activity/concentration of SOD, MDA, TAC, and ROMO1 (p < 0.001; p = 0.0013; p < 0.001; p = 0.003).
  • While RMF can reduce oxidative stress (notably higher SOD and CAT in controls than in RMF-exposed samples), prolonged RMF at 50 Hz increased TAC levels, suggesting enhanced oxidative stress under certain exposure conditions.
  • Optimal RMF exposure for minimizing oxidative stress: 1h at 50 Hz for SOD and MDA; 3h at 25 Hz for CAT and TAC.
  • For ROMO1, 1h at 25 Hz prevented increased ROS production.

Conclusion

This experimental evidence shows direct biological effects of rotating magnetic fields on oxidative stress-related systems in healthy humans. The results highlight that while RMF may reduce oxidative stress under controlled conditions, certain exposure modes could intensify oxidative stress, affirming the need for careful safety evaluation of EMF exposure in human environments and supporting the connection between electromagnetic field exposure and health risks.

magnetic field oxidative stress antioxidants reactive oxygen species human volunteers SOD TAC
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