Effect of 900 MHz GSM Mobile Phone RF Radiation on Estrogen Receptor Methylation Status in Colon Cells

Abstract

Abstract Overview

Rising concerns about the biological effects of radiofrequency radiation from mobile phones have been noted, with extensive research focusing on its impact on various physiological systems and its association with cancer through epigenetic pathways like gene promoter methylation.

Research Goals and Methodology

The study investigated if radiofrequency radiation affects the epigenetic pattern of the Estrogen Receptor α (ERα) in colon cells of male Sprague Dawley rats. It also explored the concept of radioadaptive responses after subsequent exposure to gamma radiation.

• Subjects: 40 male Sprague-Dawley rats divided into four groups.
• Exposure: Groups received varying exposures to GSM cell phone radiation and Co-60 gamma radiation.
• Assessment: Methylation status of the ERα gene was evaluated using methylation-specific PCR.

Key Findings

The exposure to GSM cell phone RF radiation altered the methylation pattern of the ERα gene compared to non-exposed controls. Interestingly, no adaptive response was observed in the ERα gene methylation pattern after gamma radiation exposure, suggesting a potential detrimental impact of RF radiation on genetic integrity.

Conclusion

The study highlights the potential epigenetic risks of RF radiation from GSM mobile phones, emphasizing its role in the alteration of gene methylation patterns which could contribute to diseases like colorectal cancer.