Modulation of voltage-gated calcium influx by electromagnetic irradiation with terahertz Gaussian pulse

Authors: Wenfei Bo, Lianghao Guo, Kaicheng Wang, Jialu Ma, Jingchao Tang, Zhe Wu, Baoqing Zeng, Yubin Gong

Year: Jul 21, 2020

Category: Electrophysiology

Journal: IEEE Access

DOI: 10.1109/ACCESS.2020.3010870

URL: https://ieeexplore.ieee.org/document/9145579

Abstract

Overview

The study explores the impact of terahertz Gaussian pulse radiation on voltage-gated calcium influxes. The research evaluates temperature rise and its effects in this context.

Findings

  • Inhibition of voltage-gated calcium influx is evident with increasing amplitude of terahertz Gaussian pulses.
  • Compared to the sinusoidal wave, Gaussian pulses significantly mitigate this inhibition effect.
  • Modulation by Gaussian pulses results in lower concurrent temperature rise for the same increase in intracellular calcium concentration than with sinusoidal waves.
  • Consistent dependency of calcium concentration increments on the irradiated duration and frequency seen with sinusoidal waves is maintained with Gaussian pulse irradiation.

Conclusion

The research delineates the non-thermal effects of terahertz Gaussian pulse modulation on calcium influx, pointing towards possible clinical applications due to reduced thermal drawbacks.

electromagnetic fields terahertz radiation calcium influx voltage-gated channels thermal effects
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