Investigation of bias related to differences between case and control interview dates in five INTERPHONE countries
Abstract
Overview
This study examines potential biases in epidemiological data regarding the association between cellular telephone use and glioma risk.
Findings
- No general positive association found between cellular telephone use and glioma risk.
- Elevated risks were noted among individuals in the highest decile of cumulative call time.
- The likelihood of bias due to differences in interview timings between cases and controls during periods of increasing cellular telephone use.
Methods
Analyses were conducted using a post-hoc matching strategy across five INTERPHONE study countries to optimize the timing and age similarity of interviews between cases and controls.
Conclusion
Improved interview timing proximity is crucial in studies where exposure patterns change rapidly over time, highlighting the necessity for careful study design to mitigate timing bias.