Zinc affects nuclear factor kappa b and DNA methyltransferase activity in C3H cancer fibroblast cells induced by a 2100 MHz electromagnetic field

Authors: D Duzgun Ergun, N Pastaci Ozsobaci, T Yilmaz, D Ozcelik, M T Kalkan

Year: 2022 Jan 7

Category: Biomedical Research

Journal: Electromagn Biol Med

Institution: Electromagn Biol Med

DOI: 10.1080/15368378.2021.2019760

URL: https://pubmed.ncbi.nlm.nih.gov/34994293

Abstract

Overview

The rapid increase in mobile phone usage has raised significant concerns about the potential health impacts of electromagnetic fields (EMF). This study explores the effects of EMF and zinc supplementation on cancer fibroblast cells.

Findings

  • Cell viability increased under 2100 MHz EMF exposure but decreased when zinc was supplemented.
  • Significant increases in nuclear factor kappa b (NF-κB) and DNA methyltransferase (DNMT) activities were observed in cells exposed to 2100 MHz EMF alone.
  • Zinc supplementation at 50, 100, and 200 µM levels alongside EMF exposure led to a decrease in both NF-κB and DNMT activities, indicating the protective role of zinc against EMF effects.

Conclusion

The study underscores the potential hazards of EMF exposure on cellular activities linked to cancer progression and highlights the mitigating effects of zinc. These findings suggest that zinc supplementation could be a valuable approach in reducing EMF-induced cellular changes.

electromagnetic field cancer fibroblast cells DNA methyltransferase NF-kB zinc supplementation
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