Myocardial capacity of mitochondrial oxidative phosphorylation in response to prolonged electromagnetic stress

Abstract

Overview

The study investigates the impact of continuous exposure to electromagnetic fields (EMFs) on mitochondrial oxidative phosphorylation (OXPHOS) and cardiac structure in mice.

Methods

• Exposure of mice to 915 MHz electromagnetic fields for 28 days to study mitochondrial changes and myocardium structure.

Findings

Mitochondrial analysis showed increased expression of OXPHOS Complexes I-IV proteins with unchanged α-subunit of ATP synthase levels. Although mitochondrial respiratory capacity was altered, oxidative stress markers and structural assessments of left ventricles showed no significant changes.

Discussion

Prolonged EMF exposure could alter mitochondrial metabolic processes in cardiac cells, potentially leading to metabolic and functional adjustments without notable oxidative or structural damage in the myocardium.

Conclusion

This research underscores the subtle yet significant mitochondrial adjustments in cardiac cells due to EMF exposure, emphasizing the need for further exploration into the long-term effects of EMFs on cardiovascular health.