Effects of ELF EMF on Neurogenesis and Cognitive Behavior in an Experimental Model of Hippocampal Injury

Authors: Sakhaie MH, Soleimani M, Pourheydar B, Majd Z, Atefimanesh P, Asl SS, Mehdizadeh M

Year: 2017

Category: Neuroscience

Journal: Behav Neurol

Institution: Behav Neurol

DOI: 10.1155/2017/9194261

URL: https://www.ncbi.nlm.nih.gov/pubmed/29259353

Abstract

Overview

Exposure to extremely low-frequency electromagnetic fields (ELF-EMF) is a growing area of interest due to potential impacts on human neurology and behavior.

Findings

  • This study investigates the effects of ELF-EMF on neurogenesis and memory using a mouse model with induced hippocampal injury through trimethyltin chloride.
  • Mice were tested on spatial memory using the Morris water maze, showing significant improvement in memory among those exposed to ELF-EMF.
  • Immunohistochemistry and Western blot analyses indicated increased neurogenesis and neuronal differentiation in the hippocampus.
  • Significant upregulation of NeuroD2 was observed, suggesting enhanced neuronal plasticity.

Conclusion

The study provides evidence that ELF-EMF exposure enhances neurogenesis and spatial memory, offering potential therapeutic insights for neurodegenerative diseases and cognitive decline associated with aging.

ELF EMF neurogenesis cognitive behavior hippocampal injury neuronal plasticity
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