Effects of electromagnetic fields on neuronal ion channels: a systematic review

Authors: Federico Bertagna, Rebecca Lewis, S Ravi P Silva, Johnjoe McFadden, Kamalan Jeevaratnam

Year: 2021 May 4

Category: Neuroscience

Journal: Ann N Y Acad Sci

Institution: Ann N Y Acad Sci

DOI: 10.1111/nyas.14597

URL: https://pubmed.ncbi.nlm.nih.gov/33945157/

Abstract

Overview

Many aspects of chemistry and biology are mediated by electromagnetic field (EMF) interactions, with the central nervous system (CNS) showing particular sensitivity. This study presents a systematic review of the last two decades of research into the effects of EMFs on the electrical properties of neurons, focusing on voltage-gated ion channels (VGCs).

Findings

22 papers were included following a systematic search according to PRISM guidelines.
Significant changes were observed in calcium homeostasis, specifically linked to voltage-gated calcium channels.
The effects of EMFs varied greatly depending on the field’s frequency, exposure time, and tissue properties like VGC expression.
Diverse modulatory effects on neuronal ion channels including gating dynamics, ion conductance, and gene/protein expression were noted.

Conclusion

This comprehensive review systematically clarifies the complex interactions between EMFs and neuronal ion channels and their potential health implications. Given the highlighted significant correlations, the results demand careful consideration regarding EMF exposure and raise questions about its safety.

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