A high-resolution pediatric female whole-body numerical model with comparison to a male model
Abstract
Overview
Recent advancements in pediatric numerical models have spurred the development of "Athena," a high-resolution and anatomically detailed whole-body model tailored for a female child, addressing the gap in sex representation in pediatric models.
Objective
Numerical models serve crucial roles in medical device design and physiological studies. Limited pediatric models and scant representation of sexes prompted the development of a sophisticated pediatric female model.
Approach
- Utilized MRI and CT imaging to segment body tissues of a 3.5-year-old healthy female.
- Anatomical accuracy validated by experienced neuro-radiologists with sex-differentiated organ metrics assessments.
- Comparison with a male model "Martin" showcased anatomical and organ metric distinctions alongside MRI dosimetric exposure.
Main results
The model includes 267 tissue compartments with 50 brain tissue labels, adhering closely to established healthy child metrics. Furthermore, it demonstrates the capability to calculate Specific Absorption Rate (SAR) and Joule heating in young children during a 7T MRI.
Significance
The "Athena" model transcends mere anatomical detailing to support radiofrequency safety evaluations for medical devices, neurostimulation, and radiation dosimetry studies. This open-source model is a significant stride in pediatric imaging and medical safety research.
Access and Use
"Athena" is available as an open-source resource on the Athinoula A. Martinos Center for Biomedical Imaging website, promoting widespread academic and clinical application.