Potential factors affecting chronic chemical intolerance associated with constitutional predisposition or lifestyle and environment during childhood: From a six-year follow-up study

Abstract

Overview

The Japanese chemical intolerance (JCI) study, beginning in January 2012, surveyed 7245 adults to explore the impact of childhood environmental and constitutional factors on the development of chronic chemical intolerance (CI).

Methods

• In this follow-up study, 4683 participants were reassessed after six years.
• Data collection involved self-reported questionnaires that examined CI status, medical history, and various childhood exposures.

Findings

From 2500 respondents, significant data emerged:

• There is a notable correlation between chronic CI and childhood experiences of motion sickness and allergic conjunctivitis.
• Environmental factors such as proximity to high-voltage power lines and exposure to strong perfumes and chemical odors in childhood can potentially increase CI risk.
• Conversely, the use of carpets and plaster coatings in homes during childhood showed a potential decrease in CI risk.

Conclusion

Early-life environmental and constitutional factors significantly contribute to the development of chronic chemical intolerance. Key factors include inherent autonomic susceptibility and childhood exposures to various environmental stresses.