1800 MHz Radiofrequency Electromagnetic Field Impairs Neurite Outgrowth Through Inhibiting EPHA5 Signaling

Abstract

Overview

The study explores the impact of environmental radiofrequency electromagnetic fields (RF-EMF), which has risen public health concerns, particularly regarding its influence on brain development. Techniques such as high-throughput RNA sequencing were utilized to investigate the effects.

Findings

• Exposure to 1800 MHz RF-EMF notably decreased neurite length and the number of branch points in derived neurons and Neuro-2A cells.
• EPHA5 receptor expression, critical for neurite outgrowth, was significantly suppressed following RF-EMF exposure.
• Introduction of enhanced EPHA5 signaling could negate the detrimental effects of RF-EMF on neurite outgrowth.
• Key downstream factors like CREB and RhoA were identified as significant mediators in the harmful interference of RF-EMF with neurite development.

Conclusion

The results demonstrate the inhibitory effects of 1800 MHz RF-EMF exposure on neurite outgrowth and provide insights into the mechanisms and key signaling pathways affected, offering a startling glimpse into how RF-EMF could influence brain development.