A regulatory pathway model of neuropsychological disruption in Havana syndrome

Authors: Chacko TP, Toole JT, Morris MC, Page J, Forsten RD, Barrett JP, Reinhard MJ, Brewster RC, Costanzo ME, Broderick G

Year: 2023 Oct 27

Category: Neuropsychology, Psychiatry

Journal: Front Psychiatry

Institution: Front Psychiatry

DOI: 10.3389/fpsyt.2023.1180929

URL: https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1180929/full

Abstract

Overview

This study examines neuropsychological disruptions similar to those seen in cases of mild traumatic brain injury (mTBI), which were reported by diplomatic personnel in Havana since 2016. These incidents are referred to as Anomalous Health Incidents (AHI).

Method

  • Utilization of automated text-mining techniques on over 9,000 publications.
  • Creation of a comprehensive network model examining 273 regulatory interactions involving 29 neuro-chemical markers and 9 neuropsychological constructs.

Findings

The analysis revealed characteristic expressions of specific neuro-chemical markers such as elevated IL-1B, IL-10, and others, corresponding to observed symptoms. Predictions also show a slow recovery trajectory for affected subjects.

Conclusion

Disruption in neurotransmission and neuro-inflammatory pathways notably contributes to the neuropsychological symptoms observed in Havana syndrome, similar to patterns seen in mTBI. Ongoing recovery suggests a dynamic adjustment rather than a permanent state of illness.

Havana syndrome neuropsychological disruption neuroimmune mechanisms neurotransmission computational analysis
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