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Exposure Of Human Peripheral Blood Lymphocytes To Electromagnetic Fields
Associated With Cellular Phones Leads To Chromosomal Instability (Abstract)
Department of Human Genetics and Molecular Medicine, Tel-Aviv University
Mashevich M, Folkman D, Kesar A, Barbul A, Korenstein R, Jerby E, Avivi L.
February 24, 2003
Whether exposure to radiation emitted from cellular phones poses a health hazard
is at the focus of current debate. We have examined whether in vitro exposure of
human peripheral blood lymphocytes (PBL) to continuous 830 MHz electromagnetic
fields causes losses and gains of chromosomes (aneuploidy), a major "somatic
mutation" leading to genomic instability and thereby to cancer. PBL were
irradiated at different average absorption rates (SAR) in the range of 1.6-8.8
W/kg for 72 hr in an exposure system based on a parallel plate resonator at
temperatures ranging from 34.5-37.5 degrees C. The averaged SAR and its
distribution in the exposed tissue culture flask were determined by combining
measurements and numerical analysis based on a finite element simulation code. A
linear increase in chromosome 17 aneuploidy was observed as a function of the
SAR value, demonstrating that this radiation has a genotoxic effect. The SAR
dependent aneuploidy was accompanied by an abnormal mode of replication of the
chromosome 17 region engaged in segregation (repetitive DNA arrays associated
with the centromere), suggesting that epigenetic alterations are involved in the
SAR dependent genetic toxicity. Control experiments (i.e., without any RF
radiation) carried out in the temperature range of 34.5-38.5 degrees C showed
that elevated temperature is not associated with either the genetic or
epigenetic alterations observed following RF radiation-the increased levels of
aneuploidy and the modification in replication of the centromeric DNA arrays.
These findings indicate that the genotoxic effect of the electromagnetic
radiation is elicited via a non-thermal pathway. Moreover, the fact that
aneuploidy is a phenomenon known to increase the risk for cancer, should be
taken into consideration in future evaluation of exposure guidelines.
Bioelectromagnetics 24:82-90, 2003.
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